一、产品名称
尊龙凯时推出的Anti-PEGAntibody,亦称为PEG抗体。
二、产品描述
尊龙凯时的PEG(聚乙二醇)是一种由重复的乙二醇单元构成的化合物,其特点包括高亲水性、无毒性及无抗原性,具备良好的生物兼容性。PEG化修饰能显著改变药物的物理化学性质,延长血浆半衰期和吸收时间,同时影响药物与细胞受体的结合亲和力,提高肿瘤靶向性。在PEG化修饰药物的研发中,抗PEG抗体作为重要的研究工具,可以监测药物的药代动力学,如分布、代谢与排泄,同时还可用于聚乙二醇化蛋白质或分子(如纳米颗粒)的质量控制。尊龙凯时的Antibodysystem PEG系列抗体适用于ELISA、WB和HC等实验。
三、相关产品
- Anti-PEGAntibody(E112#)(RGK24701)
- Anti-PEGAntibody(6A9/PEG2)(RGK24702)
- Anti-PEGAntibody(14B5/PEG1a)(RGK24703)
- Anti-PEGAntibody(14B5/PEG1b)(RGK24704)
- Anti-PEGAntibody(331)(RGK24705)
- Anti-PEGAntibody(2B5)(RGK24706)
- Anti-PEGAntibody(32D6)(RGK24707)
- Anti-PEGAntibody(AGP3)(RGK24708)
- Anti-PEGAntibody(63)(RGK24709)
- Anti-PEGAntibody(15-2b)(RGK24710)
四、产品详情
Anti-PEGAntibody(E112#)(RGK24701)
- 别名:PEG, Poly(ethyleneglycol), Polyethyleneglycol
- 货号:RGK24701
- 宿主:Mouse
- 同种型:IgG1, kappa
- 克隆类型:Monoclonal
- 靶标:PEG, Poly(ethyleneglycol), Polyethyleneglycol
- 浓度:1mg/ml
- 内毒素水平:请与实验室联系获取相关信息
- 纯度:95%(依据SDS-PAGE测定)
- 纯化方式:Protein A/G 纯化自细胞培养上清液
- 克隆号:E112#
- 应用:ELISA, WB
- 状态:Liquid
- 保存溶液:0.01 M PBS, pH 7.4
- 稳定性和存储:使用手动解冻冰箱,避免反复冻融。短期存储于4°C(1-2周),长期存储于-20°C(12个月)或-80°C。
五、参考文献
- PMID: 27369864 - Anti-PEG antibodies in the clinic: Current issues and beyond PEGylation
- PMID: 26118102 - "PEG dilemma" for liposomes and its solving approaches
- PMID: 31336703 - Chemistry Routes for Copolymer Synthesis Containing PEG for Targeting, Imaging, and Drug Delivery Purposes
- PMID: 37355210 - Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route
- PMID: 39702782 - Exosome isolation based on polyethylene glycol (PEG): a review
- PMID: 39012983 - Quantitation of PEG on PEGylated Gold Nanoparticles Using Reversed Phase High-Performance Liquid Chromatography and Charged Aerosol Detection
- PMID: 25547369 - PEG-lipid micelles as drug carriers: physiochemical attributes, formulation principles and biological implication
- PMID: 26191379 - Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use
- PMID: 38469811 - Free PEG Suppresses Anaphylaxis to PEGylated Nanomedicine in Swine
- PMID: 35079293 - Stepwise PEG synthesis featuring deprotection and coupling in one pot
- PMID: 32024289 - The Importance of Poly(ethyleneglycol) Alternatives for Overcoming PEG Immunogenicity in Drug Delivery and Bioconjugation
- PMID: 34401032 - Missing PEG tube found at the ileocecal valve
- PMID: 30694626 - Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice
- PMID: 1458545 - The uses and properties of PEG-linked proteins
- PMID: 36641121 - Accelerated clearance by antibodies against methoxy PEG depends on pegylation architecture
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